FOOTNOTES
$In a year-long observational/surveillance registry that relied on patient reports of symptomatic adverse events that would have led them to seek clinical care, no symptomatic infiltrative events or serious adverse events were reported. These results should be considered in conjunction with other clinical results on the safety and efficacy of daily disposable etafilcon A contact lenses, which also generally show low rates of such events. Although no symptomatic infiltrative events were reported in this study, such events can and have occurred with daily disposable lenses, including 1- DAY ACUVUE MOIST, as noted in the product labeling.
#As measured by ocular coherence tomography (OCT) across a horizontal 10mm diameter of the cornea. Maximum upper 95% Cl = 1.17% swelling.
+ 14 clinical studies posted on ClinicalTrials.gov, a website maintained by the NIH, evaluated subjective comfort as a primary or secondary endpoint for 1-DAY ACUVUE® MOIST brand family (spherical, astigmatism, and multifocal) contact lenses vs. competitors’ products. Published trials include comparisons between etafilcon A and nelfilcon A, omafilcon A, hilafilcon B, ocufilcon D and nesofilcon A. Review conducted as of April 30, 2023.
$ In a year-long observational/surveillance registry that relied on patient reports of symptomatic adverse events that would have led them to seek clinical care, no symptomatic infiltrative events or serious adverse events were reported. These results should be considered in conjunction with other clinical results on the safety and efficacy of daily disposable etafilcon A contact lenses, which also generally show low rates of such events. Although no symptomatic infiltrative events were reported in this study, such events can and have occurred with daily disposable lenses, including 1-DAY ACUVUE MOIST, as noted in the product labeling.
*Source Euromonitor International Limited; based on research conducted in Sept-Nov 2022; "world" and "globally" represent markets accounting for 78% of total daily disposable contact lenses in 2021 (retail sales).
† Based on in-vitro data, clinical studies have not been done directly linking differences in lysozyme profile with specific clinical benefits.
†† Based on publicly available manufacturer information as of March 2020
‡ The release profile for PVP in 1-DAY ACUVUE MOIST over 24 hours demonstrated no detectable amount of PVP released throughout the 24-hour simulated wear period.
#Helps protect against transmission of harmful UV radiation to the cornea & into the eye
^WARNING: UV-absorbing contact lenses are NOT substitutes for protective eyewear such as UV- absorbing goggles or sunglasses because they do not completely cover the eye and surrounding area. You should continue to use UV-absorbing eyewear as directed. NOTE: Long-term exposure to UV radiation is one of the risk factors associated with cataracts. Exposure is based on a number of factors such as environmental conditions (altitude, geography, cloud cover) and personal factors (extent and nature of outdoor activities). UV-blocking contact lenses help provide protection against harmful UV radiation. However, clinical studies have not been done to demonstrate that wearing UV-blocking contact lenses reduces the risk of developing cataracts or other eye disorders. Consult your eye care practitioner for more information.
REFERENCES
1. JJV Data on File, 2022. 1-DAY ACUVUE MOIST Claims from the TEMPO Observational Registry.
2. Moezzi A, Varikooty J, Schulze M, et al. Corneal swelling with cosmetic etafilcon A lenses versus no lens wear. Optom Vis Sci. 2016;93(6):619-628. doi: 10.1097/OPX.0000000000000840.
3. JJV Data on File 2021. Dual Action Technology and “Cushion of Moisture” Description for 1- DAY ACUVUE MOIST Brand Family of Contact Lenses.
4. JJV Data on File 2022. Material Properties: 1- DAY ACUVUE MOIST, 1-DAY ACUVUE TruEye, ACUVUE OASYS 1-Day with HydraLuxe Technology and ACUVUE OASYS MAX 1- Day with TearStable Technology Brand Contact Lenses.
5. Heynen M, Omali NB, Fadli Z, et al. Selectivity and localization of lysozyme uptake in contemporary hydrogel contact lens materials. J Biomater. Sci. Polym. Ed. 2017;28(13):1351-1364. doi: 10.1080/09205063.2017.1327751.
6. JJV Data on File 2020. 1- DAY ACUVUE MOIST Family Parameters Coverage
7. Sterner O, Aeschlimann R, Zurcher S, et al. Friction measurements on contact lenses in a physiologically relevant environment: Effect of testing conditions on friction. Invest Ophthalmol Vis Sci. 2016,57(13):5
8. JJV Data on File 2022: Master Brand Claims on Clinical Performance and Overall Material Properties for ACUVUE Brand Soft Contact Lenses.
9. Fadli Z, Mahadevan S, Scales C. Antioxidant Capacity of a Phenolic Benzotriazole (Norbloc) in Soft Contact Lens Materials: A Benefit Beyond UV Blocking. Invest. Ophthalmol. Vis. Sci. 2018;59:1759.
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